Alström syndrome is a genetic disorder that is slowly progressive, affecting multiple organ systems. Affected individuals experience progressive degeneration of the retina, resulting in childhood blindness; mild to moderate hearing impairment; glucose intolerance (non-insulin dependent diabetes mellitus) that develops in early adulthood; childhood obesity that often moderates to high-normal weight in adulthood; progressive kidney failure; congestive heart failure that becomes apparent during infancy, adolescence, or adulthood; and/or other symptoms and findings